| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38590254 | Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38635860 | Vitamin D3 and zinc supplements augment the antimanic efficacy of lithium and olanzapine treatments in an animal model of mania |
| Curcumin | 📋 | ✍ | ⛔ | | 38672750 | Curcumin as a Multifunctional Spice Ingredient against Mental Disorders in Humans: Current Clinical Studies and Bioavailability Concerns |
| Melatonin | 📋 | ✍ | ⛔ | | 38613097 | The Positive Association between Melatonin-Containing Food Consumption and Older Adult Life Satisfaction, Psychoemotional State, and Cognitive Function |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38470647 | Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38593704 | Total ginsenosides decrease Aβ production through activating PPARγ |
| Resveratrol | 📋 | ✍ | ⛔ | | 38504306 | Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence |
| Berberine | 📋 | ✍ | ⛔ | | 38678955 | Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38654507 | Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease |
| Saffron | 📋 | ✍ | ⛔ | | 38694315 | Saffron extract as an emerging novel therapeutic option in reproduction and sexual health: recent advances and future prospectives |
| Quercetin | 📋 | ✍ | ⛔ | | 38692425 | Combination of dasatinib and quercetin alleviates heat stress-induced cognitive deficits in aged and young adult male mice |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 38490827 | The effect of lavender and bergamot oil applied via inhalation on the anxiety level and sleep quality of surgical intensive care unit patients |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 38435146 | N-acetyl Cysteine Supplementation to Alleviate Skin Picking Disorder: A Case Report |
| EGCG | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Ginseng | 📋 | ✍ | ⛔ | | 38707644 | Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38373507 | N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma |
| Vitamin C | 📋 | ✍ | ⛔ | | 38718917 | Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats |
| Ashwagandha | 📋 | ✍ | ⛔ | | 38454585 | Amelioration by Withania somnifera of neurobehavioural and immunological markers in time dependent sensitization induced post traumatic stress disorder in rats |
| Luteolin | 📋 | ✍ | ⛔ | | 38125952 | The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells |
| Crocin | 📋 | ✍ | ⛔ | | 38227208 | Interaction of aerobic exercise and crocin improves memory, learning and hypocampic tau and neurotrophins gene expression in rats treated with trimethytin as a model of Alzheimer's disease |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Micronutrients | 📋 | | ⛔ | | 38623983 | Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration |
| Metformin | 📋 | ✍ | ⛔ | | 38582410 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Medicinal Plants | 📋 | | | | 38425647 | The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials |
| Sulforaphane | 📋 | ✍ | ⛔ | | 38438062 | Sulforaphane's role in Redefining autophagic Responses in depression associated with polycystic ovarian syndrome: Unveiling the SIRT1/AMPK/LKB1 pathway connection |
| Vitamin E | 📋 | ✍ | ⛔ | | 38542534 | Tocotrienols Prevent the Decline of Learning Ability in High-Fat, High-Sucrose Diet-Fed C57BL/6 Mice |
| Magnesium | 📋 | ✍ | ⛔ | | 38213402 | Magnesium supplementation beneficially affects depression in adults with depressive disorder: a systematic review and meta-analysis of randomized clinical trials |
| Citicoline | 📋 | ✍ | ⛔ | | 38432442 | Additive anxiolytic-like effect of citicoline and ACPA in the non-acute restraint stress (NARS) and acute restraint stress (ARS) mice |
| Astaxanthin | 📋 | ✍ | ⛔ | | 38542737 | The Effects of Astaxanthin on Cognitive Function and Neurodegeneration in Humans: A Critical Review |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| CoQ10 | 📋 | ✍ | ⛔ | | 38684047 | Discovering the Potential Value of Coenzyme Q10 as an Adjuvant Treatment in Patients With Depression |
| Salidroside | 📋 | | | | 38641312 | Salidroside prevents gestational hypertension-induced impairment of offspring learning and memory via Wnt/Skp2 pathway |
| Probiotics | 📋 | ✍ | ⛔ | | 38598329 | Co-administration of probiotic and vitamin D significantly improves cognitive function in schizophrenic patients: A double-blinded randomized controlled trial |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 37163781 | Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38465655 | Dietary lipoic acid alleviates autism-like behavior induced by acrylamide in adolescent mice: the potential involvement of the gut-brain axis |
| Schisandra | 📋 | ✍ | ⛔ | | 38565361 | Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice |
| Gotu Kola | 📋 | ✍ | ⛔ | | 38703344 | Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like Behaviors, Inflammation and Oxidative Stress in Adult Rats Submitted to Stress in Early Life |
| L-Theanine | 📋 | ✍ | ⛔ | | 37697164 | L-Theanine adjunct to risperidone in the treatment of chronic schizophrenia inpatients: a randomized, double-blind, placebo-controlled clinical trial |
| Food | 📋 | | | | 38515359 | Effect of Dietary Habits on Alzheimer's Disease Progression |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 38300291 | Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of randomized controlled trials |
| Genistein | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Hesperidin | 📋 | ✍ | ⛔ | | 38107143 | Hesperidin reduces depressive symptoms in post-coronary artery bypass graft patients with mild depression |
| Selenium | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Zinc | 📋 | ✍ | ⛔ | | 38635860 | Vitamin D3 and zinc supplements augment the antimanic efficacy of lithium and olanzapine treatments in an animal model of mania |
| Valerian Root | 📋 | ✍ | ⛔ | | 35990355 | Valerian essential oil for treating insomnia via the serotonergic synapse pathway |
| Blueberry | 📋 | ✍ | ⛔ | | 37647279 | Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus |
| Fish Oil | 📋 | ✍ | ⛔ | | 38341308 | Fish oil supplementation and risk of dementia among diabetic patients: a prospective study of 16,061 older patients |
| Puerarin | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Caffeine | 📋 | ✍ | ⛔ | | 37531810 | Caffeine intake is associated with less severe depressive symptoms in noncancer populations: an analysis based on NHANES 2007-2016 |
| Ginkgolides | 📋 | | | | 38676673 | [Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease] |
| Goji Berry | 📋 | ✍ | ⛔ | | 38653878 | Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway |
| Phytochemicals | 📋 | | | | 38471283 | Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease |
| Apigenin | 📋 | ✍ | ⛔ | | 38675442 | Apigenin Alleviates Autistic-like Stereotyped Repetitive Behaviors and Mitigates Brain Oxidative Stress in Mice |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38487137 | Protective Effect of Ferulic Acid on Acetylcholinesterase and Amyloid Beta Peptide Plaque Formation in Alzheimer's Disease: An In Vitro Study |
| Icariin | 📋 | ✍ | | | 38604555 | Function and mechanism exploring of icariin in schizophrenia through network pharmacology |
| Naringin | 📋 | ✍ | ⛔ | | 37526460 | Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review |
| Baicalin | 📋 | ✍ | ⛔ | | 38631145 | Upregulation of Nrf2 signaling: A key molecular mechanism of Baicalin's neuroprotective action against diabetes-induced cognitive impairment |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38680120 | Eicosapentaenoic acid activates the P62/KEAP1/NRF2 pathway for the prevention of diabetes-associated cognitive dysfunction |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 37151621 | Ellagic acid through attenuation of neuro-inflammatory response exerted antidepressant-like effects in socially isolated mice |
| Lemon Balm | 📋 | ✍ | ⛔ | | 37927585 | The possible "calming effect" of subchronic supplementation of a standardised phospholipid carrier-based Melissa officinalis L. extract in healthy adults with emotional distress and poor sleep conditions: results from a prospective, randomised, double-blinded, placebo-controlled clinical trial |
| Lycopene | 📋 | ✍ | ⛔ | | 37871231 | Lycopene Prevents Phthalate-Induced Cognitive Impairment via Modulating Ferroptosis |
| Astragalosides | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Baicalein | 📋 | ✍ | ⛔ | | 38006681 | Baicalein promotes the microglia M2 polarization and suppresses apoptosis by targeting HMOX1/PDE4D to alleviate Alzheimer's disease |
| Coconut Oil | 📋 | | ⛔ | | 38106629 | Assessment of the neuroprotective effect of Cocos nucifera L. oil on learning and behavior impairment in ovariectomized rats |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 37482219 | Dihydromyricetin alleviates hippocampal ferroptosis in type 2 diabetic cognitive impairment rats via inhibiting the JNK-inflammatory factor pathway |
| Folate | 📋 | ✍ | ⛔ | | 37707697 | Folic Acid and Folinic Acid Protect Hearts of Aging Triple-transgenic Alzheimer's Disease mice via IGF1R/PI3K/AKT and SIRT1/AMPK Pathways |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 36839204 | Beneficial Effect of Increased Tryptophan Intake on Its Metabolism and Mental State of the Elderly |
| Olive Oil | 📋 | ✍ | ⛔ | | 38709531 | Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 38684848 | St. John's wort extract Ze 117 alters the membrane fluidity of C6 glioma cells by influencing cellular cholesterol metabolism |
| Nobiletin | 📋 | ✍ | | | 37598127 | The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism |
| Fisetin | 📋 | ✍ | ⛔ | | 38235981 | Effects of fisetin on ethanol-induced rewarding properties in mice |
| Paeoniflorin | 📋 | | | | 38703807 | Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress |
| Polyphenols | 📋 | | | | 38338814 | Attention Deficit Hyperactivity Disorder (ADHD) and Polyphenols: A Systematic Review |
| Thymoquinone | 📋 | | ⛔ | | 38031940 | Effects of thymoquinone and memantine alone and in combination on memory and hippocampal morphology in rats with streptozotocin-induced Alzheimer's disease |
| Carotenoids | 📋 | ✍ | ⛔ | | 37467792 | Plasma carotenoids and risk of depressive symptomatology in a population-based cohort of older adults |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38495146 | Prolonged oral intake of green tea polyphenols attenuates delirium-like behaviors in mice induced by anesthesia/surgery |
| Naringenin | 📋 | ✍ | ⛔ | | 38561101 | Liraglutide and Naringenin relieve depressive symptoms in mice by enhancing Neurogenesis and reducing inflammation |
| Silibinin | 📋 | ✍ | | | 38106632 | Silibinin effects on cognitive disorders: Hope or treatment? |
| Piperine | 📋 | ✍ | ⛔ | | 37878284 | A Standardized Withania somniferra (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study |
| Pterostilbene | 📋 | ✍ | ⛔ | | 38354494 | Pterostilbene alleviates cafeteria diet-induced obesity and underlying depression in adolescent male Swiss albino mice and affects insulin resistance, inflammation, HPA axis dysfunction and SIRT1 mediated leptin-ghrelin signaling |
| Rosmarinic Acid | 📋 | ✍ | | | 38103880 | Rosmarinic acid against cognitive impairment via RACK1/HIF-1α regulated microglial polarization in sepsis-surviving mice |
| Rutin | 📋 | ✍ | ⛔ | | 36902309 | A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer's Disease |
| Walnut | 📋 | | ⛔ | | 37960217 | Effects of Walnut and Pumpkin on Selective Neurophenotypes of Autism Spectrum Disorders: A Case Study |
| Chrysin | 📋 | ✍ | ⛔ | | 38538228 | Involvement of the GABAA Receptor in the Antidepressant-Like Effects Produced by Low and High Doses of the Flavonoid Chrysin in the Rat: A Longitudinal Study |
| Coffee | 📋 | ✍ | ⛔ | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Gallic Acid | 📋 | | ⛔ | | 38549642 | Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model |
| Green Tea | 📋 | ✍ | ⛔ | | 38706293 | Investigating the Impact of Tea Consumption on Cognitive Function and Exploring Tea-Genetic Interactions in Older Adults Aged 65-105 Years: Findings from the 2002-2018 CLHLS Data |
| Pomegranate | 📋 | | ⛔ | | 38074891 | A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38720773 | Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease |
| Antioxidants | 📋 | | ⛔ | | 38578890 | Association Between Composite Dietary Antioxidant Index and Cognitive Function Among Aging Americans from NHANES 2011-2014 |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 38553964 | Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons |
| Vitamin B Complex | 📋 | | ⛔ | | 36057827 | B Vitamin Supplementation Slows Cognitive Decline in Mild Cognitive Impairment Patients with Frontal Lobe Atrophy |
| Andrographolide | 📋 | | | | 37179044 | Andrographolide exerts a neuroprotective effect by regulating the LRP1-mediated PPARγ/NF-κB pathway |
| Flavonoids | 📋 | | ⛔ | | 38398799 | Effect of Polyphenol Supplementation on Memory Functioning in Overweight and Obese Adults: A Systematic Review and Meta-Analysis |
| Rosemary | 📋 | ✍ | ⛔ | | 38258779 | Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies |
| Anthocyanins | 📋 | ✍ | ⛔ | | 38455191 | Higher anthocyanin intake is associated with lower depressive symptoms in adults with and without major depressive disorder |
| Cocoa | 📋 | ✍ | ⛔ | | 38244989 | Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic sub-cohort of the COSMOS randomized clinical trial and meta-analysis of three cognitive studies within COSMOS |
| DHEA | 📋 | ✍ | ⛔ | | 38183866 | Cortisol and changes in depressive symptoms: The moderating role of DHEA |
| Lutein | 📋 | ✍ | ⛔ | | 35508396 | Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults |
| NMN | 📋 | ✍ | ⛔ | | 37447179 | Effect of Exercise and Oral Niacinamide Mononucleotide on Improving Mitochondrial Autophagy in Alzheimer's Disease |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36810840 | Sex-specific susceptibility to psychotic-like states provoked by prenatal THC exposure: Reversal by pregnenolone |
| Skullcap | 📋 | ✍ | ⛔ | | 38645989 | Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 35813593 | The Protective Effects of Zeaxanthin on Amyloid-β Peptide 1-42-Induced Impairment of Learning and Memory Ability in Rats |
| Cinnamon | 📋 | ✍ | ⛔ | | 38696678 | Antidepressant-Like Effects of Cinnamomum verum on Open-Space Forced Swim-Induced Depression in Mice |
| Geniposide | 📋 | | | | 38232800 | Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 36703196 | Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial |
| Prebiotics | 📋 | ✍ | ⛔ | | 38589690 | Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder |
| PUFA | 📋 | | | | 37046127 | Circulating polyunsaturated fatty acids, fish oil supplementation, and risk of incident dementia: a prospective cohort study of 440,750 participants |
| Tea | 📋 | | | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Choline | 📋 | ✍ | ⛔ | | 38721665 | Choline chloride shows gender-dependent positive effects on social deficits, learning/memory impairments, neuronal loss and neuroinflammation in the lipopolysaccharide-induced rat model of autism |
| Essential Oils | 📋 | | ⛔ | | 37619300 | Effects of aromatherapy on depression: A meta-analysis of randomized controlled trials |
| Frankincense | 📋 | ✍ | ⛔ | | 35385330 | Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury |
| Ginger | 📋 | ✍ | ⛔ | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| L-Arginine | 📋 | ✍ | ⛔ | | 37660966 | Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 36457653 | Effects of Aromatherapy With Citrus Aurantium Lavender on Sexual Function of Postmenopausal Women: A Randomized Controlled Trial |
| Silymarin | 📋 | ✍ | ⛔ | | 38353101 | Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease |
| Thymol | 📋 | ✍ | ⛔ | | 36842231 | Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 34638031 | Beneficial effects of natural products on female sexual dysfunction: A systematic review and meta-analysis |
| TUDCA | 📋 | ✍ | ⛔ | | 38440398 | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease |
| Betaine | 📋 | ✍ | ⛔ | | 38184996 | Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner |
| Carvacrol | 📋 | ✍ | ⛔ | | 37694395 | Carvacrol improved learning and memory and attenuated the brain tissue oxidative damage in aged male rats |
| Chamomile | 📋 | ✍ | ⛔ | | 37057581 | Effect of Chamomile Vaginal Gel on the Sexual Function in Postmenopausal Women: A Double-Blind Randomized Controlled Trial |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Fish | 📋 | | ⛔ | | 38706279 | Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 33970818 | Grape seed extract effects on hippocampal neurogenesis, synaptogenesis and dark neurons production in old mice. Can this extract improve learning and memory in aged animals? |
| Honokiol | 📋 | | | | 37481555 | SIRT3 ameliorates diabetes-associated cognitive dysfunction via regulating mitochondria-associated ER membranes |
| L-Carnitine | 📋 | ✍ | ⛔ | | 38674921 | L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 38633104 | Comparative Neuroprotective Effects of Moringa oleifera Seed Oil and Aqueous Extract on Cognitive Functions on a High-Fat, High-Fructose Diet Mice: Focus on Senescence Markers |
| Pine Bark | 📋 | ✍ | ⛔ | | 38299491 | Pycnogenol® improves cognitive function in post-stroke patients: a 6 month-study |
| Tanshinone | 📋 | | | | 38659601 | Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis |
| Taurine | 📋 | ✍ | ⛔ | | 38548872 | Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2 |
| 5-HTP | 📋 | ✍ | ⛔ | | 36550837 | Exploration of restless legs syndrome under the new concept: A review |
| Allicin | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38583392 | Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 37248896 | Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease |
| Catalpol | 📋 | | | | 37551177 | Catalpol Alleviates Depression by Inhibiting NLRP3 Inflammasome via TLR4/MAPK/NF-Kb Pathway |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38046466 | Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway |
| Grape | 📋 | | ⛔ | | 36342065 | Grape juice reduces the effects of amyloid β aggregation phenotype and extends the longevity in Caenorhabditis elegans |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 38248449 | Hericium erinaceus Extract Exerts Beneficial Effects on Gut-Neuroinflammaging-Cognitive Axis in Elderly Mice |
| Magnolia | 📋 | ✍ | ⛔ | | 33950239 | A honokiol-enriched Magnolia officinalis Rehder & E.H. Wilson. bark extract possesses anxiolytic-like activity with neuroprotective effect through the modulation of CB1 receptor |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Spikenard | 📋 | ✍ | ⛔ | | 35864434 | Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 38601615 | Association of vitamin B1 intake with geriatric cognitive function: An analysis of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014 |
| Vitamins | 📋 | | | | 38397800 | A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Angelica | 📋 | ✍ | ⛔ | | 38154524 | Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice |
| Asiaticoside | 📋 | | | | 37569347 | Asiaticoside Mitigates Alzheimer's Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38143280 | Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling |
| Crocetin | 📋 | | | | 37935859 | Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes |
| Fenugreek | 📋 | ✍ | ⛔ | | 37231762 | Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease |
| Formononetin | 📋 | | | | 37403720 | [Formononetin improves cognitive behavior in aging rats with chronic unpredictable mild in hippocampal tissue stress by blocking the NF-κB pathway and inhibiting the release of inflammatory factors] |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 38331341 | Fucoxanthin mitigates valproic acid-induced autistic behavior through modulation of the AKT/GSK-3β signaling pathway |
| Ganoderic Acid | 📋 | | | | 38723681 | Ganoderic acid A ameliorates depressive-like behaviors in CSDS mice: Insights from proteomic profiling and molecular mechanisms |
| Gardenia | 📋 | | ⛔ | | 38000495 | Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome |
| Garlic | 📋 | ✍ | ⛔ | | 38563400 | The association between raw garlic consumption and the risk of depressive symptoms: the TCLSIH cohort study |
| Hesperetin | 📋 | | | | 38517352 | Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| Myricetin | 📋 | | ⛔ | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Nicotinamide | 📋 | ✍ | ⛔ | | 37775016 | Nicotinamide, an acetylcholinesterase uncompetitive inhibitor, protects the blood‒brain barrier and improves cognitive function in rats fed a hypercaloric diet |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 38379607 | Black seed oil reverses chronic antibiotic-mediated depression and social behaviour deficits via modulation of hypothalamic mitochondrial-dependent markers and insulin expression |
| Oleuropein | 📋 | | | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Persimmon | 📋 | | ⛔ | | 35668445 | Persimmon leaf extract alleviates chronic social defeat stress-induced depressive-like behaviors by preventing dendritic spine loss via inhibition of serotonin reuptake in mice |
| Salvianolic Acid | 📋 | | | | 37913602 | Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization |
| Schisandrins | 📋 | | | | 37910285 | Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 33839493 | Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 38435630 | Alpha-Linolenic Acid Ameliorates Cognitive Impairment and Liver Damage Caused by Obesity |
| Echinacoside | 📋 | | | | 38569512 | Beneficial effects of Echinacoside on cognitive impairment and diabetes in type 2 diabetic db/db mice |
| Fucoidan | 📋 | ✍ | ⛔ | | 36876791 | Fucoidans inhibited tau interaction and cellular uptake |
| GABA | 📋 | ✍ | ⛔ | | 38321713 | GABA Supplementation, Increased Heart-Rate Variability, Emotional Response, Sleep Efficiency and Reduced Depression in Sedentary Overweight Women Undergoing Physical Exercise: Placebo-Controlled, Randomized Clinical Trial |
| Holy Basil | 📋 | ✍ | ⛔ | | 38657467 | Bioactive compounds from Ocimum tenuiflorum and Poria cocos: A novel natural Compound for insomnia treatment based on A computational approach |
| Hydroxytyrosol | 📋 | | | | 38680105 | Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition |
| Irisin | 📋 | | | | 38658376 | Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases |
| L-Carnosine | 📋 | ✍ | ⛔ | | 36946070 | Cognitive and negative symptoms in schizophrenia with L-Carnosine adjuvant therapy - A randomized double-blind placebo-controlled study |
| Linalool | 📋 | | ⛔ | | 38723901 | Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation |
| Magnolol | 📋 | | | | 38183534 | The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice |
| Mangiferin | 📋 | | ⛔ | | 37521470 | Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats: possible antioxidant and anti-inflammatory mechanisms |
| Mushrooms | 📋 | | ⛔ | | 38634265 | Investigating the association between inflammation mediated by mushroom consumption and mild cognitive impairment in Chinese older adults |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Spirulina | 📋 | ✍ | ⛔ | | 36861852 | The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial |
| Tangeretin | 📋 | | | | 36216079 | Tangeretin prevents cognitive deficit in delirium through activating RORα/γ-E4BP4 axis in mice |
| Urolithins | 📋 | | | | 37667442 | Urolithin A Protects Neuronal Cells against Stress Damage and Apoptosis by Atp2a3 Inhibition |
| Vitamin A | 📋 | ✍ | ⛔ | | 36728544 | Combinations of Vitamin A and Vitamin E Metabolites Confer Resilience against Amyloid-β Aggregation |
| Vitamin K | 📋 | ✍ | ⛔ | | 37032783 | Association between vitamin K intake and depressive symptoms in US adults: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018 |
| Asiatic Acid | 📋 | | | | 33802221 | Asiatic Acid Prevents Cognitive Deficits by Inhibiting Calpain Activation and Preserving Synaptic and Mitochondrial Function in Rats with Kainic Acid-Induced Seizure |
| Astragalus Root | 📋 | ✍ | ⛔ | | 38301982 | Antidepressant potential of total flavonoids from Astragalus in a chronic stress mouse model: Implications for myelination and Wnt/β-catenin/Olig2/Sox10 signaling axis modulation |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36982248 | β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| Bilobalide | 📋 | | | | 37615035 | Suppressive effects of bilobalide on depression-like behaviors induced by chronic unpredictable mild stress in mice |
| Black Pepper | 📋 | ✍ | ⛔ | | 34778972 | A standardized black pepper seed extract containing β-caryophyllene improves cognitive function in scopolamine-induced amnesia model mice via regulation of brain-derived neurotrophic factor and MAPK proteins |
| Catechins | 📋 | | | | 36150679 | (-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity |
| Chokeberry | 📋 | ✍ | ⛔ | | 35040318 | Cyanidin 3- O-β-Galactoside Alleviated Cognitive Impairment in Mice by Regulating Brain Energy Metabolism During Aging |
| Cinnamaldehyde | 📋 | | | | 36432096 | Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil and Its Main Component Cinnamaldehyde in Animal Models |
| Cordycepin | 📋 | | | | 38294969 | Dose-dependent action of cordycepin on the microbiome-gut-brain-adipose axis in mice exposed to stress |
| Dihydroquercetin | 📋 | | | | 38694040 | Pharmacological investigation of taxifolin for its therapeutic potential in depression |
| Diosgenin | 📋 | | | | 38705555 | The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism |
| Diosmin | 📋 | ✍ | ⛔ | | 38092305 | Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex |
| Haritaki | 📋 | ✍ | ⛔ | | 38329710 | Evaluation of the biological efficiency of Terminalia chebula fruit extract against neurochemical changes induced in brain of diabetic rats: an epigenetic study |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Lavender | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Lotus | 📋 | | ⛔ | | 36757040 | Procyanidins extracted from the lotus seedpod ameliorate cognitive impairment through CREB-BDNF pathway mediated LTP in APP/PS1 transgenic mice |
| PEA | 📋 | ✍ | ⛔ | | 36387000 | Therapeutic effect of palmitoylethanolamide in cognitive decline: A systematic review and preliminary meta-analysis of preclinical and clinical evidence |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Strawberry | 📋 | ✍ | ⛔ | | 33547659 | Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease |
| Wormwood | 📋 | ✍ | ⛔ | | 36999542 | Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Anise | 📋 | ✍ | ⛔ | | 34451620 | Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Carnosic Acid | 📋 | | | | 36331794 | Carnosic Acid Mitigates Depression-Like Behavior in Ovariectomized Mice via Activation of Nrf2/HO-1 Pathway |
| Coconut | 📋 | | ⛔ | | 29188860 | A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged |
| Emodin | 📋 | | ⛔ | | 38405501 | Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review |
| Fermented Foods | 📋 | | ⛔ | | 38280441 | Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: A systematic review of clinical trials |
| Geraniol | 📋 | | | | 38703789 | Alcohol exacerbates psychosocial stress-induced neuropsychiatric symptoms: Attenuation by geraniol |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 38453099 | Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1/2-dependent pathways |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36765376 | Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy |
| Kaempferol | 📋 | ✍ | ⛔ | | 38587532 | Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice |
| Kudzu Root | 📋 | ✍ | ⛔ | | 33433542 | In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway |
| Ligustilide | 📋 | | | | 38394737 | Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features |
| Mangosteen | 📋 | ✍ | ⛔ | | 35415207 | Effects of water-soluble mangosteen extract on cognitive function and neuropsychiatric symptoms in patients with mild to moderate Alzheimer's disease (WECAN-AD): A randomized controlled trial |
| Neroli Essential Oil | 📋 | ✍ | ⛔ | | 37684883 | Effects of Aroma Inhalation Therapy on Stress, Anxiety, Depression, and the Autonomic Nervous System in High-risk Pregnant Women |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 32430240 | Pomegranate-derived anthocyanin regulates MORs-cAMP/CREB-BDNF pathways in opioid-dependent models and improves cognitive impairments |
| SAMe | 📋 | ✍ | ⛔ | | 38423354 | Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis |
| Sesamol | 📋 | | | | 37333469 | Neuroprotective effects of sesamol against LPS-induced spatial learning and memory deficits are mediated via anti-inflammatory and antioxidant activities in the rat brain |
| Acai Berry | 📋 | ✍ | ⛔ | | 36405951 | Açaà ( Euterpe oleracea) pulp-enriched diet induces anxiolytic-like effects and improves memory retention |
| Aspirin | 📋 | | ⛔ | | 37509038 | A Mild Dose of Aspirin Promotes Hippocampal Neurogenesis and Working Memory in Experimental Ageing Mice |
| Basil | 📋 | ✍ | ⛔ | | 37154241 | Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 38142848 | Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice |
| Black Tea | 📋 | ✍ | ⛔ | | 37483967 | Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37864768 | Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches |
| Coptis Chinensis | 📋 | | ⛔ | | 38306514 | A network pharmacology method explores the molecular mechanism of Coptis chinensis for the treatment of Alzheimer's disease |
| Cordyceps | 📋 | ✍ | ⛔ | | 36521708 | Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway |
| Cyanidin | 📋 | ✍ | | | 38705400 | Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling |
| Date | 📋 | | ⛔ | | 36654869 | Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study |
| Fruits | 📋 | | | | 38347678 | Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Galangin | 📋 | | | | 36834819 | Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment |
| Gingerol | 📋 | ✍ | | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| Hyperoside | 📋 | | | | 36821955 | Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice |
| Icaritin | 📋 | | | | 37990437 | Icaritin greatly attenuates β-amyloid-induced toxicity in vivo |
| Inulin | 📋 | ✍ | ⛔ | | 38376033 | Inulin alters gut microbiota to alleviate post-stroke depressive-like behavior associated with the IGF-1-mediated MAPK signaling pathway |
| Krill Oil | 📋 | ✍ | ⛔ | | 37937381 | Long-Term Krill Oil Administration Alleviated Early Mild Cognitive Impairment in APP/PS1 Mice |
| Nootkatone | 📋 | | | | 36401752 | Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation |
| Paeonol | 📋 | | | | 37164258 | Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice |
| Patchouli | 📋 | ✍ | ⛔ | | 38419848 | Pogostemon cablin essential oil affects anxiety- and depressive-like behaviors and the gut microbiota in chronic unpredictable mild stress model rats |
| Peony | 📋 | | ⛔ | | 37295570 | Paeonia lactiflora Pall. Polysaccharide alleviates depression in CUMS mice by inhibiting the NLRP3/ASC/Caspase-1 signaling pathway and affecting the composition of their intestinal flora |
| Phytoestrogens | 📋 | | ⛔ | | 38292511 | Is there a difference between the effects of phytoestrogens and non-phytoestrogens medicinal plants on sexual health? A systematic review and meta-analysis |
| PQQ | 📋 | ✍ | ⛔ | | 38454653 | Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease |
| Rhodiola | 📋 | ✍ | ⛔ | | 34714119 | Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia through Activating AMPK/Nrf2 Pathway in Rats |
| Safranal | 📋 | | | | 37910529 | Effect of safranal or candesartan on 3-nitropropionicacid-induced biochemical, behavioral and histological alterations in a rat model of Huntington's disease |
| Sage | 📋 | ✍ | ⛔ | | 35137748 | Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model |
| Scutellarin | 📋 | | | | 35964195 | Scutellarin Modulates the Microbiota-Gut-Brain Axis and Improves Cognitive Impairment in APP/PS1 Mice |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 37485660 | Flavonoids from Seabuckthorn ( Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice |
| Turmeric | 📋 | ✍ | ⛔ | | 35674299 | Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 32416962 | Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 34199021 | Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment |
| Whey Protein | 📋 | ✍ | ⛔ | | 38137233 | Protective Effects of Whey Protein Hydrolysate, Treadmill Exercise, and Their Combination against Scopolamine-Induced Cognitive Deficit in Mice |
| Almond | 📋 | | ⛔ | | 33448906 | Effects of daily almond consumption for six months on cognitive measures in healthy middle-aged to older adults: a randomized control trial |
| Apple | 📋 | | ⛔ | | 35167638 | Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression- and anxiety-like behavior in mice by abating oxidative stress, inflammation and apoptosis via the miR-22-3p/SIRT1 axis |
| Artemisinin | 📋 | | | | 38454322 | Artemisinin ameliorates cognitive decline by inhibiting hippocampal neuronal ferroptosis via Nrf2 activation in T2DM mice |
| BCAA | 📋 | ✍ | ⛔ | | 37424284 | Branched-Chain Amino Acids as Adjunctive-alternative Treatment in Patients with Autism: a pilot study |
| Bee Venom | 📋 | ✍ | ⛔ | | 37317907 | Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35790009 | Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice |
| Cardamom | 📋 | ✍ | ⛔ | | 36781058 | Cardamom oil ameliorates behavioral and neuropathological disorders in a rat model of depression induced by reserpine |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Creatine | 📋 | ✍ | ⛔ | | 33589676 | Creation of a gene expression portrait of depression and its application for identifying potential treatments |
| Fiber | 📋 | ✍ | ⛔ | | 38142919 | Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 36076547 | Radix polygoni multiflori protects against hippocampal neuronal apoptosis in diabetic encephalopathy by inhibiting the HDAC4/JNK pathway |
| Ginger extract | 📋 | ✍ | ⛔ | | 34679261 | Zingiber officinale (Ginger) hydroalcoholic extract improved avoidance memory in rat model of streptozotocin-induced diabetes by regulating brain oxidative stress |
| Indian Gooseberry | 📋 | | ⛔ | | 36738163 | Preventive effect of Indian gooseberry (Phyllanthus emblica L.) fruit extract on cognitive decline in high-fat diet (HFD)-fed rats |
| Isoliquiritigenin | 📋 | | | | 36740106 | Isoliquiritigenin ameliorates paroxetine-induced sexual dysfunction in male albino mice |
| Lactobacillus plantarum | 📋 | | ⛔ | | 38373323 | Lactobacillus plantarum LLY-606 Supplementation Ameliorates the Cognitive Impairment of Natural Aging in Mice: The Potential Role of Gut Microbiota Homeostasis |
| Licorice Root | 📋 | ✍ | ⛔ | | 38074876 | Antidepressant effect of licorice total flavonoids and liquiritin: A review |
| Neferine | 📋 | | | | 37891552 | Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Nuts | 📋 | | ⛔ | | 37542950 | Nut consumption is associated with a lower risk of depression in adults: A prospective analysis with data from the UK Biobank cohort |
| Oleanolic Acid | 📋 | | | | 37812895 | Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice |
| Olive Polyphenols | 📋 | | | | 30510619 | Effects of Long-Term Treatment with a Blend of Highly Purified Olive Secoiridoids on Cognition and Brain ATP Levels in Aged NMRI Mice |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Perilla | 📋 | ✍ | | | 37355083 | Antidepressant effect of Perilla frutescens essential oil through monoamine neurotransmitters and BDNF/TrkB signal pathway |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Red Sage | 📋 | ✍ | ⛔ | | 34217797 | Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease |
| Roselle | 📋 | ✍ | ⛔ | | 38193451 | An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia |
| Sesamin | 📋 | ✍ | | | 36847969 | Effects of sesamin on Aβ1-42-induced oxidative stress and LTP impairment in a rat model of Alzheimer's disease |
| Soy | 📋 | ✍ | ⛔ | | 37818605 | Effect of dietary supplementation with multinutrient soy flour on body composition and cognitive function in elderly individuals at the risk of low protein: a randomized, double-blind, placebo-controlled study |
| Soy Isoflavones | 📋 | ✍ | ⛔ | | 37009142 | Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination |
| Spermidine | 📋 | | | | 38401586 | Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation |
| Tetrahydrocurcumin | 📋 | ✍ | | | 35723652 | Tetrahydrocurcumin Ameliorates Acute Hypobaric Hypoxia-Induced Cognitive Impairment in Mice |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 37541369 | Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 37723526 | Dietary niacin intake in relation to depression among adults: a population-based study |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Acacetin | 📋 | | | | 36382256 | Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway |
| Anthocyanidins | 📋 | | | | 37474898 | Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007-2010 and 2017-2018) |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34323669 | Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD |
| Asparagus | 📋 | | ⛔ | | 37650072 | Effect of a Standardized Extract of Asparagus officinalis Stem (ETAS®50) on Cognitive Function, Psychological Symptoms, and Behavior in Patients with Dementia: A Randomized Crossover Trial |
| Astragalin | 📋 | | | | 36681681 | Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice |
| Balloon Flower | 📋 | ✍ | ⛔ | | 38491972 | Platycodin D Ameliorates Cognitive Impairment in Type 2 Diabetes Mellitus Mice via Regulating PI3K/Akt/GSK3β Signaling Pathway |
| Bee Pollen | 📋 | ✍ | ⛔ | | 37110206 | Bee Pollen and Probiotics' Potential to Protect and Treat Intestinal Permeability in Propionic Acid-Induced Rodent Model of Autism |
| Berries | 📋 | | | | 29401686 | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
| Bilberry | 📋 | ✍ | ⛔ | | 32003387 | Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Blackberry | 📋 | | ⛔ | | 38430352 | Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling |
| Butyrate | 📋 | | ⛔ | | 38409852 | Sodium butyrate ameliorates high glucose-suppressed neuronal mitophagy by restoring PRKN expression via inhibiting the RELA-HDAC8 complex |
| Capsaicin | 📋 | ✍ | ⛔ | | 37373321 | A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease |
| Casein Protein | 📋 | ✍ | ⛔ | | 37867495 | Combination of Walnut Peptide and Casein Peptide alleviates anxiety and improves memory in anxiety mices |
| Cherry | 📋 | | ⛔ | | 36181653 | Antidepressant effects of cherry leaf decoction on a chronic unpredictable mild stress rat model based on the Glu/GABA-Gln metabolic loop |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Copper | 📋 | ✍ | ⛔ | | 36195639 | Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study |
| Cranberry | 📋 | ✍ | ⛔ | | 35662954 | Chronic Consumption of Cranberries ( Vaccinium macrocarpon) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study |
| Dioscin | 📋 | | | | 36077321 | Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits |
| Diosmetin | 📋 | | | | 38460078 | Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats |
| Eugenol | 📋 | | | | 38444813 | Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits |
| Giloy | 📋 | ✍ | ⛔ | | 35966795 | Dietary Supplementation With Tinospora cordifolia Improves Anxiety-Type Behavior and Cognitive Impairments in Middle-Aged Acyclic Female Rats |
| Hypericin | 📋 | | | | 37734259 | Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions |
| Iron | 📋 | ✍ | ⛔ | | 34836314 | The Role of Iron and Zinc in the Treatment of ADHD among Children and Adolescents: A Systematic Review of Randomized Clinical Trials |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Leucine | 📋 | ✍ | ⛔ | | 37358784 | Revealing the role of leucine in improving the social avoidance behavior of depression through a combination of untargeted and targeted metabolomics |
| Liquiritigenin | 📋 | | | | 33965487 | Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease |
| Liquiritin | 📋 | | | | 38074876 | Antidepressant effect of licorice total flavonoids and liquiritin: A review |
| Maca Root | 📋 | ✍ | ⛔ | | 36831858 | Oral Supplementation with Maca Improves Social Recognition Deficits in the Valproic Acid Animal Model of Autism Spectrum Disorder |
| Maitake Mushrooms | 📋 | | ⛔ | | 32450016 | A Polysaccharide Extract from Maitake Culinary-Medicinal Mushroom, Grifola frondosa (Agaricomycetes) Ameliorates Learning and Memory Function in Aluminum Chloride-Induced Amnesia in Mice |
| Morin | 📋 | | | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Onion | 📋 | ✍ | ⛔ | | 38722415 | Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 35866081 | A Dietary Supplement Containing Micronutrients, Phosphatidylserine, and Docosahexaenoic Acid Counteracts Cognitive Impairment in D-Galactose-Induced Aged Rats |
| Plum | 📋 | | ⛔ | | 37783584 | Plum-blossom needle therapy for Tourette syndrome: A case report |
| Polydatin | 📋 | ✍ | | | 36802487 | Polydatin Alleviates Chronic Stress-Induced Depressive and Anxiety-like Behaviors in a Mouse Model |
| Poria Mushrooms | 📋 | ✍ | | | 38657467 | Bioactive compounds from Ocimum tenuiflorum and Poria cocos: A novel natural Compound for insomnia treatment based on A computational approach |
| Progesterone | 📋 | ✍ | ⛔ | | 38147491 | Progesterone Attenuates the Stress Response in Individuals with Alcohol Dependence and Post-Traumatic Stress Disorder - A Pilot Study |
| Punicalagin | 📋 | ✍ | ⛔ | | 37092799 | Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice |
| Sage Essential Oil | 📋 | | ⛔ | | 37612717 | Effect of Salvia officinalis scent on postmenopausal women's sexual function and satisfaction: a randomized controlled trial |
| Seafood | 📋 | | | | 38706279 | Fish and Shellfish Consumption, Cognitive Health and Mortality from Alzheimer's Disease among US Adults Aged 60 and Older |
| Stigmasterol | 📋 | | | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Syringic Acid | 📋 | | | | 34599991 | Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37712018 | A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease |
| Tea Polyphenols | 📋 | | | | 38286317 | Targeting ERS-mitophagy in hippocampal neurons to explore the improvement of memory by tea polyphenols in aged type 2 diabetic rats |
| Telmisartan | 📋 | | ⛔ | | 37355897 | Telmisartan Alleviates Alzheimer's Disease-Related Neuropathologies and Cognitive Impairments |
| Theaflavins | 📋 | ✍ | | | 36718846 | Theaflavins in Black Tea Mitigate Aging-Associated Cognitive Dysfunction via the Microbiota-Gut-Brain Axis |
| Trans-Resveratrol | 📋 | | | | 34402024 | Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial |
| Trehalose | 📋 | | ⛔ | | 35906351 | Trehalose Attenuates Learning and Memory Impairments in Aged Rats via Overexpression of miR-181c |
| Wine | 📋 | | ⛔ | | 35943074 | Long term effects of red wine consumption in brain: an MRI, fMRI and neuropsychological evaluation study |
| Withanolides | 📋 | | | | 33424246 | Withametelin: a biologically active withanolide in cancer, inflammation, pain and depression |
| Wogonin | 📋 | ✍ | ⛔ | | 33147823 | Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation |
| Aloe Vera | 📋 | ✍ | ⛔ | | 33879444 | Anxiolytic and memory enhancing potential of aloe vera and flax seed oil in rats: A comparative study with valproic acid |
| Aloe-Emodin | 📋 | | | | 37191091 | Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 29356981 | Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus |
| Beets | 📋 | ✍ | ⛔ | | 35239683 | The Insight of In Silico and In Vitro evaluation of Beta vulgaris phytochemicals against Alzheimer's disease targeting acetylcholinesterase |
| Bergamot | 📋 | ✍ | ⛔ | | 30847114 | Efficacy of bergamot: From anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations |
| Beta-Cryptoxanthin | 📋 | | | | 35508396 | Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults |
| Biochanin A | 📋 | | | | 35338989 | Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice |
| Brazil Nut | 📋 | | ⛔ | | 35052615 | Selenomethionine Ameliorates Cognitive Impairment, Decreases Hippocampal Oxidative Stress and Attenuates Dysbiosis in D-Galactose-Treated Mice |
| Bromelain | 📋 | ✍ | ⛔ | | 37076960 | Effect of Bromelain on Chronic Unpredictable Stress-induced Behavioral, Biochemical, and Monoamine Changes in Wistar Albino Rat Model of Depression |
| Calcium | 📋 | ✍ | ⛔ | | 36478774 | Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study |
| Carrot | 📋 | | ⛔ | | 33183662 | Evaluation of the effect of carrot seed (Daucus Carota) in women of fertile age with hypoactive sexual desire disorder: A randomized double-blind clinical trial |
| Cashew | 📋 | | ⛔ | | 38002521 | Cashew ( Anacardium occidentale) Extract: Possible Effects on Hypothalamic-Pituitary-Adrenal (HPA) Axis in Modulating Chronic Stress |
| Cheese | 📋 | | ⛔ | | 38694223 | Association between cheese and fish consumption and the occurrence of depression based on European population: mediating role of metabolites |
| Chrysanthemum | 📋 | ✍ | ⛔ | | 37520324 | Anxiolytic effects of Chrysanthemum morifolium Ramat Carbonisata-based carbon dots in mCPP-induced anxiety-like behavior in mice: a nature-inspired approach |
| Cinnamic Acid | 📋 | | | | 35325888 | Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 36432096 | Anxiolytic-like Effect of Inhaled Cinnamon Essential Oil and Its Main Component Cinnamaldehyde in Animal Models |
| Coriander | 📋 | | ⛔ | | 37513187 | Coriandrum sativum and Its Utility in Psychiatric Disorders |
| Coumaric acid | 📋 | | | | 37414223 | p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model |
| D-Limonene | 📋 | ✍ | ⛔ | | 33564342 | Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress |
| Daidzein | 📋 | ✍ | ⛔ | | 37619620 | Constituent isoflavones of Puerariae radix as a potential neuroprotector in cognitive impairment: Evidence from preclinical studies |
| Dandelion | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| Echinacea | 📋 | ✍ | ⛔ | | 31876052 | Double-blind Placebo Controlled Trial of the Anxiolytic Effects of a Standardized Echinacea Extract |
| Elderberry | 📋 | ✍ | ⛔ | | 38673938 | Feasibility and Preliminary Efficacy of American Elderberry Juice for Improving Cognition and Inflammation in Patients with Mild Cognitive Impairment |
| Essential Amino Acids | 📋 | ✍ | ⛔ | | 34836128 | Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study |
| Essential Fatty Acids | 📋 | ✍ | | | 33337250 | Nutritional interventions for the prevention of cognitive impairment and dementia in developing economies in East-Asia: a systematic review and meta-analysis |
| Eucommia | 📋 | ✍ | ⛔ | | 35754707 | Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter |
| Fat | 📋 | | | | 36986159 | Dietary Fats and Cognitive Status in Italian Middle-Old Adults |
| Genipin | 📋 | | | | 37865990 | Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease |
| Geranium Essential Oil | 📋 | | ⛔ | | 32888828 | Comparing the effects of geranium aromatherapy and music therapy on the anxiety level of patients undergoing inguinal hernia surgery: A clinical trial |
| Guggulsterone | 📋 | | | | 35714682 | Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Hops | 📋 | ✍ | ⛔ | | 37101856 | Effect of Humulus lupulus L. (Hop) on Postmenopausal Sexual Dysfunction: A Randomized Clinical Trial |
| Isorhamnetin | 📋 | | | | 37754268 | Unraveling the Potential of Isorhamnetin as an Adjuvant in Depression Treatment with Escitalopram |
| Jujube | 📋 | | ⛔ | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| L-Alanine | 📋 | ✍ | ⛔ | | 33503956 | Phytochemical and Psychotropic Research of Motherwort ( Leonurus cardiaca L.) Modified Dry Extracts |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Lysine | 📋 | ✍ | ⛔ | | 35696944 | Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study |
| L-Tyrosine | 📋 | ✍ | ⛔ | | 12959424 | Plasma amino acids profiles in children with autism: potential risk of nutritional deficiencies |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 35190270 | Effectiveness of lemon essential oil in reducing test anxiety in nursing students |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 36859399 | Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome |
| Lychee | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Matcha Tea | 📋 | | | | 36771286 | Matcha Tea Powder's Antidepressant-like Effect through the Activation of the Dopaminergic System in Mice Is Dependent on Social Isolation Stress |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 35339625 | Seed extract of Thai Mucuna pruriens (L.) DC. var. pruriens enhances sexual performance and improves male reproductive damages in ethanol-induced rats |
| Myrtle | 📋 | ✍ | ⛔ | | 33475094 | Myrtus communis improves cognitive impairment in renovascular hypertensive rats |
| NAD | 📋 | | | | 35956406 | Supplementation with NAD + and Its Precursors to Prevent Cognitive Decline across Disease Contexts |
| Nattokinase | 📋 | ✍ | ⛔ | | 37466380 | Nattokinase Promotes Post-stroke Neurogenesis and Cognition Recovery via Increasing Circulating Irisin |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35201555 | A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 24236576 | NMDA receptors and the L-arginine-nitric oxide-cyclic guanosine monophosphate pathway are implicated in the antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice |
| Pelargonidin | 📋 | | | | 35694918 | Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study |
| Pumpkin | 📋 | | ⛔ | | 37960217 | Effects of Walnut and Pumpkin on Selective Neurophenotypes of Autism Spectrum Disorders: A Case Study |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 37006627 | Cucurbita maxima Seeds Reduce Anxiety and Depression and Improve Memory |
| Raspberry | 📋 | ✍ | ⛔ | | 31328696 | Red raspberry ( Rubus ideaus) supplementation mitigates the effects of a high-fat diet on brain and behavior in mice |
| Rehmannia | 📋 | ✍ | ⛔ | | 35784741 | Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Rosehip | 📋 | ✍ | ⛔ | | 37088237 | Rosa canina L. improves learning and memory-associated cognitive impairment by regulating glucose levels and reducing hippocampal insulin resistance in high-fat diet/streptozotocin-induced diabetic rats |
| Safflower | 📋 | ✍ | ⛔ | | 35198336 | The Use of Safflower (Carthamus tinctorius) in Treating Depression and Anxiety |
| Senolytics | 📋 | | | | 37874084 | Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics |
| Sesame Oil | 📋 | | ⛔ | | 33049345 | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| Shilajit | 📋 | ✍ | ⛔ | | 37513872 | Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease |
| Theobromine | 📋 | ✍ | ⛔ | | 38713055 | Theobromine improves hyperactivity, inattention, and working memory via modulation of dopaminergic neural function in the frontal cortex of spontaneously hypertensive rats |
| Thyme | 📋 | ✍ | ⛔ | | 38039009 | Effects of orally administered Thymus vulgaris leaves on memory, anxiety, depression, and sleep quality in university students: a randomized controlled trial |
| Tongkat Ali | 📋 | ✍ | ⛔ | | 28259255 | Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies |
| Vegetables | 📋 | | | | 37405378 | Increased Intake of Vegetables and Fruits Improves Cognitive Function among Chinese Oldest Old: 10-Year Follow-Up Study |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 36991113 | Dietary riboflavin intake in relation to psychological disorders in Iranian adults: an observational study |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 36543778 | Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation |
| Vitex | 📋 | ✍ | ⛔ | | 37849864 | Vitagnus an estrogen-riched herbal remedy used in sexual dysfunction: A randomized clinical trial |
| Withaferin A | 📋 | | | | 34204308 | Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives |
| Yiang Yiang Essential Oil | 📋 | | ⛔ | | 35551977 | Ylang-ylang (Cananga odorata (Lam.) Hook. f. & Thomson) essential oil reduced neuropathic-pain and associated anxiety symptoms in mice |
| Anethole | 📋 | | | | 38145174 | Anethole via increase in the gene expression of PI3K/AKT/mTOR mitigates the autistic-like behaviors induced by maternal separation stress in mice |
| Apple Polyphenols | 📋 | | ⛔ | | 38406886 | Apple polyphenol extract ameliorates sugary-diet-induced depression-like behaviors in male C57BL/6 mice by inhibiting the inflammation of the gut-brain axis |
| Asafoetida | 📋 | ✍ | ⛔ | | 36857494 | Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease |
| Barley | 📋 | ✍ | ⛔ | | 36087390 | Effect of aqueous extract of barley and wheat grass in stress induced depression in Swiss mice |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36902074 | The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease |
| Black Pepper Essential Oil | 📋 | | ⛔ | | 33997409 | Anxiolytic and antidepressant-like effects of essential oil from the fruits of Piper nigrum Linn. (Black pepper) in mice: involvement of serotonergic but not GABAergic transmission system |
| Boric Acid | 📋 | ✍ | ⛔ | | 37220543 | Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease |
| Burdock | 📋 | | ⛔ | | 34439529 | 1,3-Dicaffeoylquinic Acid as an Active Compound of Arctium lappa Root Extract Ameliorates Depressive-Like Behavior by Regulating Hippocampal Nitric Oxide Synthesis in Ovariectomized Mice |
| Calycosin | 📋 | | | | 36195188 | Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease |
| Camellia | 📋 | | ⛔ | | 36466393 | Combining effect of camellia oil and squalene on hyperlipidemia-induced reproductive damage in male rats |
| Camphor Essential Oil | 📋 | | ⛔ | | 38621882 | [Essential oil of Cinnamomum camphora mitigates depression-like behavior in mice by regulating Nrf2/HO-1 pathway and inhibiting inflammatory cytokines] |
| Celery | 📋 | | ⛔ | | 36334223 | Beneficial effects of celery seed extract (Apium graveolens), as a supplement, on anxiety and depression in hypertensive patients: a randomized clinical trial |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38053824 | Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system |
| Chicoric Acid | 📋 | | | | 38542381 | Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36028179 | Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels |
| Cryptotanshinone | 📋 | | | | 38011787 | Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms |
| Dairy | 📋 | | | | 37492650 | Dairy products intake and the risk of postpartum depression among mothers: A pilot study |
| Dihydroartemisinin | 📋 | | | | 38552734 | Dihydroartemisinin protects mice from CUMS-induced depression-like behaviors and regulates gut microbes |
| DMAE | 📋 | ✍ | ⛔ | | 12844472 | Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states |
| Docosapentaenoic Acid | 📋 | ✍ | | | 35166302 | Twelve Weeks of Additional Fish Intake Improves the Cognition of Cognitively Intact, Resource-Limited Elderly People: A Randomized Control Trial |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 32522946 | Fish Oil and Primrose Oil Suppress the Progression of Alzheimer's Like Disease Induced by Aluminum in Rats |
| Fennel | 📋 | ✍ | ⛔ | | 33708258 | The Effect of Jazar Supplement on Quality of Life and Sexual Function in Postmenopausal Women: A Double-Blind, Randomized, Placebo-Controlled Trial |
| Flaxseed Oil | 📋 | ✍ | ⛔ | | 33879444 | Anxiolytic and memory enhancing potential of aloe vera and flax seed oil in rats: A comparative study with valproic acid |
| Frankincense Essential Oil | 📋 | | ⛔ | | 18753801 | [Effects of aroma hand massage on pain, state anxiety and depression in hospice patients with terminal cancer] |
| Ginger Essential Oil | 📋 | ✍ | | | 19853815 | Effectiveness of the essential oils lavender and ginger in promoting children's comfort in a perianesthesia setting |
| Glycine | 📋 | ✍ | ⛔ | | 37237908 | GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Old Mice Improves Brain Glutathione Deficiency, Oxidative Stress, Glucose Uptake, Mitochondrial Dysfunction, Genomic Damage, Inflammation and Neurotrophic Factors to Reverse Age-Associated Cognitive Decline: Implications for Improving Brain Health in Aging |
| Grapefruit Essential Oil | 📋 | ✍ | ⛔ | | 33463729 | Effects of diffused essential oils for reducing stress and improving mood for clinical nurses: An interventional time series study |
| Hazelnut | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| Hyaluronic Acid | 📋 | ✍ | ⛔ | | 33930204 | Hyaluronic acid injection in the glans penis for the treatment of refractory premature ejaculation: A prospective, controlled study |
| Iodine | 📋 | ✍ | ⛔ | | 32802419 | The Relationship between Iodine and Selenium Levels with Anxiety and Depression in Patients with Euthyroid Nodular Goiter |
| Isoflavones | 📋 | ✍ | ⛔ | | 35740885 | Dietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults |
| Kava Root | 📋 | ✍ | ⛔ | | 33207379 | Kava (Piper methysticum) Extract for the Treatment of Nervous Anxiety, Tension and Restlessness |
| Lecithin | 📋 | ✍ | ⛔ | | 37009142 | Role of soy lecithin combined with soy isoflavone on cerebral blood flow in rats of cognitive impairment and the primary screening of its optimum combination |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 37207879 | The potential of lemon balm (Melissa officinalis L.) essential oil as an anti-anxiety agent - is the citronellal the activity carrier? |
| Lemon Verbena | 📋 | | ⛔ | | 34153940 | Salvia officinalis and Lippia triphylla: Chemical characterization and evaluation of antidepressant-like activity |
| Licochalcones | 📋 | | | | 37762479 | Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment |
| Loquat | 📋 | ✍ | ⛔ | | 37513484 | Dried Loquat Fruit Extract Containing Chlorogenic Acid Prevents Depressive-like Behaviors Induced by Repeated Corticosteroid Injections in Mice |
| Madecassoside | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Mango | 📋 | | ⛔ | | 35344129 | Antidepressant activity of phytochemicals of Mangifera indica seeds assisted by integrated computational analysis |
| Marjoram Essential Oil | 📋 | | ⛔ | | 38045619 | Inhalation of Origanum majorana L. essential oil while working reduces perceived stress and anxiety levels of nurses in a COVID-19 intensive care unit: a randomized controlled trial |
| Minerals | 📋 | | | | 38244989 | Effect of multivitamin-mineral supplementation versus placebo on cognitive function: Results from the clinic sub-cohort of the COSMOS randomized clinical trial and meta-analysis of three cognitive studies within COSMOS |
| Neem | 📋 | ✍ | | | 35198760 | Anxiolytic and antidepressant-like activities of aqueous extract of Azadirachta indica A. Juss. flower in the stressed rats |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Omega-6 Fatty Acids | 📋 | ✍ | ⛔ | | 31991898 | The Effects of a 6-Month High Dose Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins Supplementation on Cognitive Function and Functional Capacity in Older Adults with Mild Cognitive Impairment |
| Osmanthus | 📋 | ✍ | ⛔ | | 28917370 | Aromatherapies using Osmanthus fragrans oil and grapefruit oil are effective complementary treatments for anxious patients undergoing colonoscopy: A randomized controlled study |
| Papaya | 📋 | ✍ | ⛔ | | 37626269 | Phytochemical Extract from Carica papaya Leaves and Punica granatum Seeds as Therapy Against Cognitive Impairment in a Murine Model |
| Parsley | 📋 | | ⛔ | | 33916097 | The Potential of Parsley Polyphenols and Their Antioxidant Capacity to Help in the Treatment of Depression and Anxiety: An In Vivo Subacute Study |
| Parthenolide | 📋 | | | | 37992573 | Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway |
| Pear | 📋 | | ⛔ | | 34602398 | Determination of anxiolytic and antidepressant like activity of hydro alcoholic fruit extract of Pyrus communis (L.) and its impact on the memory after chronic dosing in animal models |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pistachio | 📋 | ✍ | ⛔ | | 29881519 | Effects of a food product (based on Daucus carota) and education based on traditional Persian medicine on female sexual dysfunction: a randomized clinical trial |
| Pomegranate Seed extract | 📋 | | ⛔ | | 38306046 | The Effects of Pomegranate Seed Oil on Mild Cognitive Impairment |
| Procyanidins | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 30692033 | B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study |
| Red Yeast Rice | 📋 | ✍ | ⛔ | | 34048842 | Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation |
| Retinoic Acid | 📋 | | | | 37247722 | Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model |
| Royal Jelly | 📋 | ✍ | ⛔ | | 36809522 | Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Shogaol | 📋 | | | | 35036685 | 6-Shogaol Attenuates Traumatic Brain Injury-Induced Anxiety/Depression-like Behavior via Inhibition of Oxidative Stress-Influenced Expressions of Inflammatory Mediators TNF-α, IL-1β, and BDNF: Insight into the Mechanism |
| Soy Protein | 📋 | ✍ | ⛔ | | 36561237 | Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia |
| Spices | 📋 | | | | 34279199 | Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Tamarind | 📋 | | ⛔ | | 35481086 | The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches |
| Tomato | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Yogurt | 📋 | | ⛔ | | 38306036 | The Relationship Between Fermented Dairy Consumption with Cognitive Function Among Older US Adults: Data from the NHANES 2011-2014 |
| Yohimbine | 📋 | ✍ | | | 34889886 | Investigation of Antidepressant Properties of Yohimbine by Employing Structure-Based Computational Assessments |
| Aloin | 📋 | | | | 30959371 | Aloin attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway |
| Arachidonic Acid | 📋 | ✍ | ⛔ | | 36904193 | Association between Arachidonic Acid and the Risk of Schizophrenia: A Cross-National Study and Mendelian Randomization Analysis |
| Arctiin | 📋 | | | | 32609480 | Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation |
| Argan Oil | 📋 | ✍ | ⛔ | | 32353590 | Argan oil supplementation attenuates voluntary ethanol consumption and withdrawal syndrome promoted by adolescent intermittent ethanol in rat |
| Arjuna | 📋 | ✍ | ⛔ | | 28939021 | Terminalia arjuna bark extract attenuates picrotoxin-induced behavioral changes by activation of serotonergic, dopaminergic, GABAergic and antioxidant systems |
| Atractylodes | 📋 | ✍ | ⛔ | | 36164880 | [Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway] |
| Avocado | 📋 | ✍ | ⛔ | | 34722611 | US Older Adults That Consume Avocado or Guacamole Have Better Cognition Than Non-consumers: National Health and Nutrition Examination Survey 2011-2014 |
| Avocado Oil | 📋 | | ⛔ | | 26180820 | Avocado Oil Improves Mitochondrial Function and Decreases Oxidative Stress in Brain of Diabetic Rats |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Barberry | 📋 | ✍ | ⛔ | | 36186093 | Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells |
| Bay Leaf | 📋 | | ⛔ | | 37689325 | Neuroprotective and anti-amnesic effects of Laurus Nobilis essential oil against scopolamine-induced memory deficits in mice brain |
| Beta-Alanine | 📋 | ✍ | ⛔ | | 36839281 | Role of β-Alanine Supplementation on Cognitive Function, Mood, and Physical Function in Older Adults; Double-Blind Randomized Controlled Study |
| Black Ginger | 📋 | ✍ | ⛔ | | 36904098 | Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia |
| Bread | 📋 | | | | 38528644 | Sourdough bread as nutritional intervention tool for improvement of cognitive dysfunction in diabetic rats |
| Buckwheat | 📋 | | ⛔ | | 35807886 | Buckwheat Flour and Its Starch Prevent Age-Related Cognitive Decline by Increasing Hippocampal BDNF Production in Senescence-Accelerated Mouse Prone 8 Mice |
| Cabbage | 📋 | | ⛔ | | 37781995 | Red Cabbage Anthocyanins Attenuate Cognitive Impairment By Attenuating Neuroinflammation and Regulating Gut Microbiota in Aging Mice |
| Cantaloupe | 📋 | | ⛔ | | 36967516 | Neuropharmacological evaluation of different species of Curcubitaceae seeds extract in experimental animals |
| Carbohydrates | 📋 | | | | 36539697 | Association of low-carbohydrate-diet score and cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) |
| Cardamonin | 📋 | | | | 36672126 | The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease |
| Carnosol | 📋 | | | | 35973126 | Carnosol Reduced Pathogenic Protein Aggregation and Cognitive Impairment in Neurodegenerative Diseases Models via Improving Proteostasis and Ameliorating Mitochondrial Disorders |
| Cat's Claw | 📋 | ✍ | ⛔ | | 17294693 | Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40) |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Citral | 📋 | | | | 36322162 | Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions |
| Clary Sage Essential Oil | 📋 | ✍ | ⛔ | | 23444964 | Chronic food administration of Salvia sclarea oil reduces animals' anxious and dominant behavior |
| Clove Essential Oil | 📋 | | ⛔ | | 37119836 | Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| Cornus | 📋 | | | | 34689137 | Loganin substantially ameliorates molecular deficits, pathologies and cognitive impairment in a mouse model of Alzheimer's disease |
| Diallyl Disulfide | 📋 | | | | 33511484 | Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress |
| DIM | 📋 | ✍ | ⛔ | | 35461819 | 3,3'-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice |
| Eclipta Alba | 📋 | ✍ | | | 38562322 | Investigation of the Cognitive Activity Between the Leaf Extracts of Eclipta alba and Ziziphus jujuba in Diabetic Animal Models |
| Egg | 📋 | | ⛔ | | 36650485 | Egg consumption reduces the risk of depressive symptoms in the elderly: findings from a 6-year cohort study |
| Eleuthero | 📋 | ✍ | ⛔ | | 38545117 | Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway |
| Equol | 📋 | ✍ | ⛔ | | 34038497 | S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity |
| Eucalyptol | 📋 | | | | 35028340 | Baiap3 regulates depressive behaviors in mice via attenuating dense core vesicle trafficking in subsets of prefrontal cortex neurons |
| Eucalyptus | 📋 | ✍ | ⛔ | | 35298858 | Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial |
| Fig | 📋 | | ⛔ | | 24938828 | Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| Gamma-Linolenic Acid | 📋 | ✍ | ⛔ | | 36834108 | The Effect of Neoglandin on the Activity of N-Acetyl-β-D-Hexosaminidase in the Serum and Urine of Alcohol-Dependent Men |
| Garlic Oil | 📋 | | ⛔ | | 37435927 | Garlic essential oil ameliorates depression-like behaviors in unpredictable chronic mild stress by modulating the brain NLRP3 inflammasome pathway and influencing the gut barrier and microbiota |
| Ginkgetin | 📋 | | | | 29214278 | Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model |
| Glabridin | 📋 | | | | 23975867 | Potentiating effect of glabridin on GABAA receptor-mediated responses in dorsal raphe neurons |
| Glucosamine | 📋 | ✍ | ⛔ | | 36514123 | The role of type 2 diabetes in the association between habitual glucosamine use and dementia: a prospective cohort study |
| Glutathione | 📋 | ✍ | ⛔ | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Goat Milk | 📋 | | ⛔ | | 37110156 | The Potency of Goat Milk in Reducing the Induced Neurotoxic Effects of Valproic Acid in Rat Pups as a Rodent Model of Autism Spectrum Disorder |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Grapefruit | 📋 | | ⛔ | | 36500599 | Recovery of Naringin-Rich Flavonoid Extracts from Agroresidues with Anxiolytic- and Antidepressant-like Effects in Mice |
| Guava | 📋 | | ⛔ | | 33034100 | Anxiolytic activity of Psidium guajava in mice subjected to chronic restraint stress and effect on neurotransmitters in brain |
| HMB | 📋 | ✍ | ⛔ | | 37437568 | Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice |
| Honeysuckle | 📋 | | ⛔ | | 37863440 | Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32158393 | Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells |
| Horsetail Grass | 📋 | ✍ | ⛔ | | 21615059 | Anxiolytic Effects of Equisetum Arvense Linn. Extracts in Mice |
| Jasmine | 📋 | | ⛔ | | 35010973 | Jasmine Tea Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-like Behavior in Rats via the Gut-Brain Axis |
| Kiwifruit | 📋 | ✍ | ⛔ | | 26576196 | Antiamnesic Effect of Actinidia arguta Extract Intake in a Mouse Model of TMT-Induced Learning and Memory Dysfunction |
| Knotweed | 📋 | ✍ | ⛔ | | 25856718 | Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1-40 |
| L-Histidine | 📋 | ✍ | ⛔ | | 34836128 | Deficiency in the Essential Amino Acids l-Isoleucine, l-Leucine and l-Histidine and Clinical Measures as Predictors of Moderate Depression in Elderly Women: A Discriminant Analysis Study |
| L-Threonine | 📋 | ✍ | ⛔ | | 33491030 | The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults |
| Lauric Acid | 📋 | ✍ | | | 27430387 | Lauric Acid Stimulates Ketone Body Production in the KT-5 Astrocyte Cell Line |
| Lemon | 📋 | | ⛔ | | 38016800 | Tomato and Lemon Extracts Synergistically Improve Cognitive Function by Increasing Brain-derived Neurotrophic Factor Levels in Aged Mice |
| Lemongrass | 📋 | ✍ | ⛔ | | 28499312 | Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-Like Activity of Cymbopogon citratus in Mice |
| Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
| Lingonberry | 📋 | | ⛔ | | 26738388 | [Effects of lingonberry extraction on the mice cognitive function damaged by chronic stress] |
| Long Pepper | 📋 | | ⛔ | | 37821784 | The extract of Sclerocarya birrea, Nauclea latifolia, and Piper longum mixture ameliorates diabetes-associated cognitive dysfunction |
| Lupeol | 📋 | | | | 37447385 | A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease |
| Malvidin | 📋 | | | | 35874261 | Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property |
| Manganese | 📋 | ✍ | ⛔ | | 35369103 | Associations of Dietary Copper, Selenium, and Manganese Intake With Depression: A Meta-Analysis of Observational Studies |
| Mango Leaf | 📋 | | ⛔ | | 27537110 | Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model |
| Marigold | 📋 | ✍ | ⛔ | | 26120230 | Effect of Calendula officinalis hydroalcoholic extract on passive avoidance learning and memory in streptozotocin-induced diabetic rats |
| Marjoram | 📋 | | ⛔ | | 33266220 | Subacute Assessment of the Toxicity and Antidepressant-Like Effects of Origanum Majorana L. Polyphenols in Swiss Albino Mice |
| Milk | 📋 | | ⛔ | | 32884728 | Efficacy of low-fat milk and yogurt fortified with encapsulated vitamin D 3 on improvement in symptoms of insomnia and quality of life: Evidence from the SUVINA trial |
| Modified Citrus Pectin | 📋 | ✍ | ⛔ | | 32982368 | Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro |
| Motherwort | 📋 | ✍ | ⛔ | | 33503956 | Phytochemical and Psychotropic Research of Motherwort ( Leonurus cardiaca L.) Modified Dry Extracts |
| MUFA | 📋 | | ⛔ | | 16256248 | Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging |
| Neohesperidin | 📋 | | | | 33581209 | Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer's disease therapeutics |
| Noni | 📋 | | ⛔ | | 36188588 | Potential effects of noni ( Morinda citrifolia L.) fruits extract against obsessive-compulsive disorder in marble burying and nestlet shredding behavior mice models |
| Nuciferine | 📋 | | | | 29633800 | The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study |
| Okra | 📋 | | ⛔ | | 37358589 | Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function |
| Oleic Acid | 📋 | | ⛔ | | 34040528 | Combined Oral and Topical Application of Pumpkin ( Cucurbita pepo L.) Alleviates Contact Dermatitis Associated With Depression Through Downregulation Pro-Inflammatory Cytokines |
| Olive | 📋 | ✍ | ⛔ | | 34796529 | Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke-induced depressive-like behaviors in Sprague-Dawley rats |
| Omega-9 Fatty Acids | 📋 | | | | 26780350 | The memory-enhancing effect of erucic acid on scopolamine-induced cognitive impairment in mice |
| Oyster Mushrooms | 📋 | | ⛔ | | 34798266 | Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Peach | 📋 | | ⛔ | | 35598297 | Single-cell Transcriptomic Analysis Demonstrates the Regulation of Peach Polysaccharides on Circadian Rhythm Disturbance |
| Peanut | 📋 | | ⛔ | | 35418581 | Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function |
| Phellodendron | 📋 | ✍ | ⛔ | | 18426577 | Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial |
| Phloretin | 📋 | | | | 36793870 | Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC |
| Phytosterols | 📋 | | | | 38327787 | Cholesterol-metabolism, plant sterols, and long-term cognitive decline in older people - Effects of sex and APOEe4 |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Pineapple | 📋 | ✍ | ⛔ | | 28626484 | Cognitive enhancing of pineapple extract and juice in scopolamine-induced amnesia in mice |
| Postbiotics | 📋 | | | | 37934614 | Gut microbiome-targeted therapies for Alzheimer's disease |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| Prunella Vulgaris | 📋 | ✍ | ⛔ | | 34181959 | Screening out the anti-insomnia components from Prunella vulgaris L. based on plasma pharmacochemistry combined with pharmacodynamic experiments and UPLC-MS/MS analysis |
| Psyllium | 📋 | ✍ | ⛔ | | 31103857 | Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion |
| Pu-erh Tea | 📋 | ✍ | ⛔ | | 32992081 | Pu'er tea water extract protects against cognitive impairment in a mouse model of lipopolysaccharide-induced neuroinflammation |
| Pueraria Mirifica | 📋 | ✍ | ⛔ | | 26915634 | Neurotherapeutic Effects of Pueraria Mirifica Extract in Early- And Late-Stage Cognitive Impaired Rats |
| Pumpkin Seed Oil | 📋 | ✍ | ⛔ | | 25711042 | Evaluation of Cucurbita maxima extract against scopolamine-induced amnesia in rats: implication of tumour necrosis factor alpha |
| Rice | 📋 | | ⛔ | | 35834633 | Effect of Extract of Black Sticky Rice with Giant Embryo on Alcohol Cravings of Korean Social Drinkers: A 12-Week Randomized, Placebo-Controlled Trial |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Rose | 📋 | | | | 37078068 | Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study |
| Saw Palmetto | 📋 | ✍ | ⛔ | | 22522969 | Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Seaweeds | 📋 | | ⛔ | | 36662216 | Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future |
| Shiitake Mushrooms | 📋 | ✍ | ⛔ | | 33541370 | β-Glucan from Lentinula edodes prevents cognitive impairments in high-fat diet-induced obese mice: involvement of colon-brain axis |
| Sorghum | 📋 | | ⛔ | | 34690742 | Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Spinach | 📋 | | ⛔ | | 30577447 | Effect of a Strawberry and Spinach Dietary Supplement on Spatial Learning in Early and Late Middle-Aged Female Rats |
| Star Anise | 📋 | ✍ | ⛔ | | 24919985 | Anxiolytic-like effect of Illicium verum fruit oil, trans-anethole and related compounds in mice |
| Sugarcane | 📋 | | ⛔ | | 33123536 | Sugarcane ( Saccharum officinarum L.) Top Extract Ameliorates Cognitive Decline in Senescence Model SAMP8 Mice: Modulation of Neural Development and Energy Metabolism |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 34764755 | Deciphering the CNS anti-depressant, antioxidant and cytotoxic profiling of methanol and aqueous extracts of Trametes versicolor and molecular interactions of its phenolic compounds |
| UDCA | 📋 | ✍ | ⛔ | | 34601012 | From dried bear bile to molecular investigation: a systematic review of the effect of bile acids on cell apoptosis, oxidative stress and inflammation in the brain, across pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders |
| Vitamin B8 | 📋 | ✍ | ⛔ | | 36339275 | A Randomized, Double-Blind, Controlled Clinical Trial of Omega-3 Fatty Acids and Inositol as Monotherapies and in Combination for the Treatment of Pediatric Bipolar Spectrum Disorder in Children Age 5-12 |
| Vitexin | 📋 | | | | 32926499 | Vitexin prevents Aβ proteotoxicity in transgenic Caenorhabditis elegans model of Alzheimer's disease by modulating unfolded protein response |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
| Zingerone | 📋 | | | | 35639359 | Protective Effects of Zingerone Against Depression-Like Behavior and Biochemical Changes in Chronic Stressed Rats: Antioxidant Effects |
